Experimental Setup for Modulated Electro- Hyperthermia (mEHT) Investigations with Arbitrary Modulation and Real-Time Impedance Monitoring
C. Schulze1, E. Oberacker2,3, P.D. Veltsista2, A. Dieper2, P. Ghadjar2, W. Heinrich1, O. Bengtsson1
Published in:
Proc. 55th European Microwave Conference (EuMC 2025), Utrecht, Netherlands, Sep. 23-25, ISBN: 978-2-87487-081-1, pp. 668-671 (2025).
Abstract:
Modulated electro-hyperthermia (mEHT) is a promising approach in cancer treatment, leveraging radiofrequency (RF) energy with specific modulation patterns to enhance therapeutic selectivity. This work presents an advanced experimental setup based on the Oncotherm Kft. LabEHY-200 system, enabling precise control of RF parameters, including modulation bandwidth, power, and treatment duration. The system integrates an arbitrary waveform generator (AWG) to apply continuous wave (CW) and wideband (WB) signals, facilitating impedance and power monitoring in real time. Using human colorectal carcinoma HCT116 cells, the influence of different modulation frequencies on impedance characteristics and power dissipation was investigated. Unlike previous methods, where treatment success had to be assessed after cell analysis, this approach enables immediate evaluation of treatment efficacy, leading to significant time savings.
1 Ferdinand-Braun-Institut (FBH), Germany
2 Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, Germany
3 now with Sensius, The Netherlands
Keywords:
hyperthermia, mEHT, treatment, HCT116, radiofrequency, modulation, wideband.
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