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Treatment of the Candida subspecies Candida albicans and Candida parapsilosis with two far-UVC sources to minimise mycoses in clinical practice

J. Schleusener1, S.B. Lohan1, L. Busch1,2, K. Ghoreschi1, N. Lobo Ploch3, S. May1, S. Vogel1, J. Eberle1, M.C. Meinke1

Published in:

Mycoses, vol. 66, no. 1, pp. 25-28, doi:0.1111/myc.13521 (2023).


Fungal infections have increased considerably over the last decades, becoming progressively resistant to common drugs. UVC light has shown microbiological eradication effects, whereby the wavelength of 254 nm is strongly carcino- and mutagenic. Therefore, 222 and 233 nm, which do not significantly harm skin cells, were tested for their antifungal effects. Microbicidal doses were reached at 40 mJ/cm2 for both wavelengths, resulting in only minor superficial skin damage (<20 µm). UVC irradiation with far-UVC <240 nm represents a new opportunity to effectively eradicate even larger pathogens on tissue causing no or strongly reduced DNA and tissue damage.

1 Department of Dermatology, Venerology and Allergology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
2 Department of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Marburg, Germany
3 Ferdinand-Braun-Institut gGmbH, Leibniz-Institut für Höchstfrequenztechnik, Berlin, Germany


233 nm UVC LED, Candida, clinical application, disinfection, fungal infections, mycoses

© 2022 The Authors. Mycoses published by Wiley-VCH GmbH.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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