Biological Stimulation of the Human Skin Applying Health-Promoting Light and Plasma Sources

P. Awakowicz², N. Bibinov², M. Born⁸, B. Busse¹⁰, R. Gesche⁵, A. Helmke⁹, A. Kaemling³, V. Kolb-Bachofen⁶, R. Kovacs¹, S. Kuehn⁵, J. Liebmann⁶, N. Mertens⁹, U. Niemann⁸, C. Oplaender⁴, H.-E. Porteanu⁵, J. Scherer¹, C. Suschek⁴, W. Vioel^9,7, and D. Wandke³

¹ Aurion Anlagentechnik GmbH, Seligenstadt, Germany
² Center for Plasma Science and Technology, Ruhr-University, Bochum, Germany
³ CINOGY GmbH, Duderstadt, Germany
⁴ Clinic for Plastic Surgery, University Clinic, Aachen, Germany
⁵ Ferdinand-Braun-Institut für Höchstfrequenztechnik, Berlin, Germany
⁶ Institute for Immunobiology, Heinrich-Heine University, Duesseldorf, Germany
⁷ Laser-Laboratorium, Goettingen, Germany
⁸ Philips Research, Aachen, Germany
⁹ University of Applied Sciences and Arts, Goettingen, Germany
¹⁰ zell-kontakt GmbH, Noerten-Hardenberg, Germany

Published in:
Contrib. Plasma Phys., vol. 49, no. 9, pp. 641-647 (2009).
© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Abstract:
In the frame of BMBF project "BioLiP", new physical treatment techniques aiming at medical treatment of the human skin have been developed. The acronym BioLiP stands for "Desinfektion, Entkeimung und biologische Stimulation der Haut durch gesundheitsf¨ordernde Licht- und Plasmaquellen" (Disinfection, germ reduction and biological stimulation of the human skin by health promoting light and plasma sources). A source applying a low-temperature dielectric barrier discharge plasma (DBD) has been investigated on its effectiveness for skin disinfection and stimulation of biological material. Alternatively an atmospheric plasma source consisting of a microwave resonator combined with a solid state power oscillator has been examined. This concept which allows for a compact and efficient design avoiding external microwave power supply and matching units has been optimized with respect to nitrogen monoxide (NO) production in high yields. In both cases various application possibilities in the medical and biological domain are opened up. Light sources in the visible spectral range have been investigated with respect to the proliferation of human cell types. Intensive highly selective blue light sources based on LED technology can slow down proliferation rates without inducing toxic effects which offers new opportunities for treatments of so-called hyperproliferative skin conditions (e.g. with psoriasis or in wound healing) using UV-free light.

Keywords:
Dielectric barrier discharge, plasma medicine, plasma treatment, atmospheric pressure plasma, plasma source, microwave, microplasma, nitrogen monoxide, light source, cell-proliferation, skin disease, algorithms, medical treatment.

Full version in pdf-format.